Linking asymmetric cell division, CD8+ T cell fate, and signal strength

Jyoti Pokharel; Carmen Gerlach

Cell Reports (May 2023)

Linking asymmetric cell division, CD8+ T cell fate, and signal strength

Jyoti Pokharel,
Carmen Gerlach

Affiliations

Jyoti Pokharel: Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
Carmen Gerlach: Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden; Corresponding author

Journal volume & issue: Vol. 42, no. 5
p. 112548

Abstract

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Through live imaging of CD8+ T cells carrying a fate reporter, Gräbnitz et al. directly linked (a)symmetric division to T cell fate.1 Asymmetry during the first division ensured the generation of stem-like CD8+ T cells following strong T cell stimulation.

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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