Nature Communications (Feb 2017)
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity
- Yanqin Yu,
- Xianbo Zuo,
- Miao He,
- Jinping Gao,
- Yuchuan Fu,
- Chuanqi Qin,
- Liuyan Meng,
- Wenjun Wang,
- Yaling Song,
- Yong Cheng,
- Fusheng Zhou,
- Gang Chen,
- Xiaodong Zheng,
- Xinhuan Wang,
- Bo Liang,
- Zhengwei Zhu,
- Xiazhou Fu,
- Yujun Sheng,
- Jiebing Hao,
- Zhongyin Liu,
- Hansong Yan,
- Elisabeth Mangold,
- Ingo Ruczinski,
- Jianjun Liu,
- Mary L. Marazita,
- Kerstin U. Ludwig,
- Terri H. Beaty,
- Xuejun Zhang,
- Liangdan Sun,
- Zhuan Bian
Affiliations
- Yanqin Yu
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Xianbo Zuo
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Miao He
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Jinping Gao
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Yuchuan Fu
- Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University
- Chuanqi Qin
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Liuyan Meng
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Wenjun Wang
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Yaling Song
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Yong Cheng
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Fusheng Zhou
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Gang Chen
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Xiaodong Zheng
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Xinhuan Wang
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Bo Liang
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Zhengwei Zhu
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Xiazhou Fu
- Department of Genetics and Centre for Developmental Biology, College of Life Science, Wuhan University
- Yujun Sheng
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Jiebing Hao
- The Second Charity Hospital of Henan Province
- Zhongyin Liu
- Stomatological Hospital of Nanyang
- Hansong Yan
- Stomatological Hospital of Xiangyang
- Elisabeth Mangold
- Institute of Human Genetics, Life and Brain Center, University of Bonn
- Ingo Ruczinski
- Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University
- Jianjun Liu
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Mary L. Marazita
- Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh
- Kerstin U. Ludwig
- Institute of Human Genetics, Life and Brain Center, University of Bonn
- Terri H. Beaty
- Department of Epidemiology, School of Public Health, Johns Hopkins University
- Xuejun Zhang
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Liangdan Sun
- Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University
- Zhuan Bian
- The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- DOI
- https://doi.org/10.1038/ncomms14364
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Non-syndromic cleft lip with palate is a common birth defect of unknown aetiology. Here, the authors discover 14 new genes associated with this condition, and show genetic heterogeneity in this and other non-syndromic orofacial clefting disorders.
