Nature Communications (Mar 2021)
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
- Kevin Alicea-Torres,
- Emilio Sanseviero,
- Jun Gui,
- Jinyun Chen,
- Filippo Veglia,
- Qiujin Yu,
- Laxminarasimha Donthireddy,
- Andrew Kossenkov,
- Cindy Lin,
- Shuyu Fu,
- Charles Mulligan,
- Brian Nam,
- Gregory Masters,
- Fred Denstman,
- Joseph Bennett,
- Neil Hockstein,
- Agnieszka Rynda-Apple,
- Yulia Nefedova,
- Serge Y. Fuchs,
- Dmitry I. Gabrilovich
Affiliations
- Kevin Alicea-Torres
- The Wistar Institute
- Emilio Sanseviero
- The Wistar Institute
- Jun Gui
- Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania
- Jinyun Chen
- Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania
- Filippo Veglia
- The Wistar Institute
- Qiujin Yu
- Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania
- Laxminarasimha Donthireddy
- The Wistar Institute
- Andrew Kossenkov
- The Wistar Institute
- Cindy Lin
- The Wistar Institute
- Shuyu Fu
- The Wistar Institute
- Charles Mulligan
- Helen F. Graham Cancer Center and Research Institute
- Brian Nam
- Helen F. Graham Cancer Center and Research Institute
- Gregory Masters
- Helen F. Graham Cancer Center and Research Institute
- Fred Denstman
- Helen F. Graham Cancer Center and Research Institute
- Joseph Bennett
- Helen F. Graham Cancer Center and Research Institute
- Neil Hockstein
- Helen F. Graham Cancer Center and Research Institute
- Agnieszka Rynda-Apple
- Department of Microbiology and Immunology, Montana State University
- Yulia Nefedova
- The Wistar Institute
- Serge Y. Fuchs
- Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania
- Dmitry I. Gabrilovich
- AstraZeneca
- DOI
- https://doi.org/10.1038/s41467-021-22033-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The role of type I interferon signalling in the control of myeloid derived suppressor cells (MDSC) activity remains controversial. Here the authors show that downregulation of type I interferon receptor is observed in MDSC from cancer patients and tumor-bearing mice and is required for the activation of their immune suppressive properties.
