Nature Communications (Jun 2021)

Structural basis of substrate recognition and translocation by human ABCA4

  • Tian Xie,
  • Zike Zhang,
  • Qi Fang,
  • Bowen Du,
  • Xin Gong

DOI
https://doi.org/10.1038/s41467-021-24194-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Here, cryo-EM structures of human retinal ABCA4 transporter, either in apo state, in complex with ATP or with the physiological lipid substrate N-retinylidene-phosphatidylethanolamine (NRPE), reveal lateral opening, substrate recognition and suggest ‘lateral access and extrusion’ mechanism for ABCA-mediated lipid transport.