Nature Communications (Sep 2018)
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
- Thorunn Rafnar,
- Bjarni Gunnarsson,
- Olafur A. Stefansson,
- Patrick Sulem,
- Andres Ingason,
- Michael L. Frigge,
- Lilja Stefansdottir,
- Jon K. Sigurdsson,
- Vinicius Tragante,
- Valgerdur Steinthorsdottir,
- Unnur Styrkarsdottir,
- Simon N. Stacey,
- Julius Gudmundsson,
- Gudny A. Arnadottir,
- Asmundur Oddsson,
- Florian Zink,
- Gisli Halldorsson,
- Gardar Sveinbjornsson,
- Ragnar P. Kristjansson,
- Olafur B. Davidsson,
- Anna Salvarsdottir,
- Asgeir Thoroddsen,
- Elisabet A. Helgadottir,
- Katrin Kristjansdottir,
- Orri Ingthorsson,
- Valur Gudmundsson,
- Reynir T. Geirsson,
- Ragnheidur Arnadottir,
- Daniel F. Gudbjartsson,
- Gisli Masson,
- Folkert W. Asselbergs,
- Jon G. Jonasson,
- Karl Olafsson,
- Unnur Thorsteinsdottir,
- Bjarni V. Halldorsson,
- Gudmar Thorleifsson,
- Kari Stefansson
Affiliations
- Thorunn Rafnar
- deCODE Genetics/Amgen
- Bjarni Gunnarsson
- deCODE Genetics/Amgen
- Olafur A. Stefansson
- deCODE Genetics/Amgen
- Patrick Sulem
- deCODE Genetics/Amgen
- Andres Ingason
- deCODE Genetics/Amgen
- Michael L. Frigge
- deCODE Genetics/Amgen
- Lilja Stefansdottir
- deCODE Genetics/Amgen
- Jon K. Sigurdsson
- deCODE Genetics/Amgen
- Vinicius Tragante
- deCODE Genetics/Amgen
- Valgerdur Steinthorsdottir
- deCODE Genetics/Amgen
- Unnur Styrkarsdottir
- deCODE Genetics/Amgen
- Simon N. Stacey
- deCODE Genetics/Amgen
- Julius Gudmundsson
- deCODE Genetics/Amgen
- Gudny A. Arnadottir
- deCODE Genetics/Amgen
- Asmundur Oddsson
- deCODE Genetics/Amgen
- Florian Zink
- deCODE Genetics/Amgen
- Gisli Halldorsson
- deCODE Genetics/Amgen
- Gardar Sveinbjornsson
- deCODE Genetics/Amgen
- Ragnar P. Kristjansson
- deCODE Genetics/Amgen
- Olafur B. Davidsson
- deCODE Genetics/Amgen
- Anna Salvarsdottir
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Asgeir Thoroddsen
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Elisabet A. Helgadottir
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Katrin Kristjansdottir
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Orri Ingthorsson
- Department of Obstetrics and Gynecology, Akureyri Hospital
- Valur Gudmundsson
- Department of Obstetrics and Gynecology, Akureyri Hospital
- Reynir T. Geirsson
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Ragnheidur Arnadottir
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Daniel F. Gudbjartsson
- deCODE Genetics/Amgen
- Gisli Masson
- deCODE Genetics/Amgen
- Folkert W. Asselbergs
- Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht
- Jon G. Jonasson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Karl Olafsson
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen
- Bjarni V. Halldorsson
- deCODE Genetics/Amgen
- Gudmar Thorleifsson
- deCODE Genetics/Amgen
- Kari Stefansson
- deCODE Genetics/Amgen
- DOI
- https://doi.org/10.1038/s41467-018-05428-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.
