Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

Tiantian Fang; Wanbiao Chen; Yaping Sheng; Siming Yuan; Qiaowei Tang; Gongyu Li; Guangming Huang; Jihu Su; Xuan Zhang; Jianye Zang; Yangzhong Liu

doi:10.1038/s41467-018-08102-z

Nature Communications (Jan 2019)

Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

Tiantian Fang,
Wanbiao Chen,
Yaping Sheng,
Siming Yuan,
Qiaowei Tang,
Gongyu Li,
Guangming Huang,
Jihu Su,
Xuan Zhang,
Jianye Zang,
Yangzhong Liu

Affiliations

Tiantian Fang: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China
Wanbiao Chen: Hefei National Laboratory for Physical Sciences at Microscale CAS Center for Excellence in Biomacromolecules, Collaborative Innovation Center of Chemistry for Life Sciences, and School of Life Sciences, University of Science and Technology of China
Yaping Sheng: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China
Siming Yuan: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China
Qiaowei Tang: Department of Modern Physics, University of Science and Technology of China
Gongyu Li: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China
Guangming Huang: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China
Jihu Su: Department of Modern Physics, University of Science and Technology of China
Xuan Zhang: Hefei National Laboratory for Physical Sciences at Microscale CAS Center for Excellence in Biomacromolecules, Collaborative Innovation Center of Chemistry for Life Sciences, and School of Life Sciences, University of Science and Technology of China
Jianye Zang: Hefei National Laboratory for Physical Sciences at Microscale CAS Center for Excellence in Biomacromolecules, Collaborative Innovation Center of Chemistry for Life Sciences, and School of Life Sciences, University of Science and Technology of China
Yangzhong Liu: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-018-08102-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Tetrathiomolybdate (TM) and Cu-ATPases, e.g. Wilson (WLN) protein, affect the efficacy of common anticancer drug cisplatin. Here, the authors show that TM generates a protein dimer with a WLN domain by expelling copper and provide insight into the synergy of TM and cisplatin in cancer chemotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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