Nature Communications (Apr 2016)
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
- Sherry Y. Wu,
- Rajesha Rupaimoole,
- Fangrong Shen,
- Sunila Pradeep,
- Chad V. Pecot,
- Cristina Ivan,
- Archana S. Nagaraja,
- Kshipra M. Gharpure,
- Elizabeth Pham,
- Hiroto Hatakeyama,
- Michael H. McGuire,
- Monika Haemmerle,
- Viviana Vidal-Anaya,
- Courtney Olsen,
- Cristian Rodriguez-Aguayo,
- Justyna Filant,
- Ehsan A. Ehsanipour,
- Shelley M. Herbrich,
- Sourindra N. Maiti,
- Li Huang,
- Ji Hoon Kim,
- Xinna Zhang,
- Hee-Dong Han,
- Guillermo N. Armaiz-Pena,
- Elena G. Seviour,
- Sue Tucker,
- Min Zhang,
- Da Yang,
- Laurence J. N. Cooper,
- Rouba Ali-Fehmi,
- Menashe Bar-Eli,
- Ju-Seog Lee,
- Prahlad T. Ram,
- Keith A. Baggerly,
- Gabriel Lopez-Berestein,
- Mien-Chie Hung,
- Anil K. Sood
Affiliations
- Sherry Y. Wu
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Rajesha Rupaimoole
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Fangrong Shen
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Sunila Pradeep
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Chad V. Pecot
- Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center
- Cristina Ivan
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Archana S. Nagaraja
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Kshipra M. Gharpure
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Elizabeth Pham
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Hiroto Hatakeyama
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Michael H. McGuire
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Monika Haemmerle
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Viviana Vidal-Anaya
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Courtney Olsen
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Cristian Rodriguez-Aguayo
- Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center
- Justyna Filant
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Ehsan A. Ehsanipour
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Shelley M. Herbrich
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Sourindra N. Maiti
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Li Huang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Ji Hoon Kim
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Xinna Zhang
- Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
- Hee-Dong Han
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Guillermo N. Armaiz-Pena
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Elena G. Seviour
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Sue Tucker
- Department of Bioinformatics, The University of Texas MD Anderson Cancer Center
- Min Zhang
- Department of Pharmaceutical Sciences, University of Pittsburgh
- Da Yang
- Department of Pharmaceutical Sciences, University of Pittsburgh
- Laurence J. N. Cooper
- Division of Pediatrics, The University of Texas MD Anderson Cancer Center
- Rouba Ali-Fehmi
- Department of Pathology, Wayne State University School of Medicine, Karmanos Cancer Institute
- Menashe Bar-Eli
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Ju-Seog Lee
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Prahlad T. Ram
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Keith A. Baggerly
- Department of Bioinformatics, The University of Texas MD Anderson Cancer Center
- Gabriel Lopez-Berestein
- Department of Medicine, The University of North Carolina
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Anil K. Sood
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/ncomms11169
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.
