Synthesis of 1-(<i>para</i>-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes

Alexander  A. Titov; Reza Samavati; Elena  V. Alexandrova; Tatiana  N. Borisova; Tuyet  Anh Dang Thi; Van  Tuyen Nguyen; Tuan  Anh Le; Alexey  V. Varlamov; Erik  V. Van der Eycken; Leonid  G. Voskressensky

doi:10.3390/molecules23113010

Molecules (Nov 2018)

Synthesis of 1-(<i>para</i>-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes

Alexander A. Titov,
Reza Samavati,
Elena V. Alexandrova,
Tatiana N. Borisova,
Tuyet Anh Dang Thi,
Van Tuyen Nguyen,
Tuan Anh Le,
Alexey V. Varlamov,
Erik V. Van der Eycken,
Leonid G. Voskressensky

Affiliations

Alexander A. Titov: Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Reza Samavati: Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Elena V. Alexandrova: Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Tatiana N. Borisova: Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Tuyet Anh Dang Thi: Institute of Chemistry of Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam
Van Tuyen Nguyen: Institute of Chemistry of Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam
Tuan Anh Le: Faculty of Chemistry of VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000, Vietnam
Alexey V. Varlamov: Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Erik V. Van der Eycken: Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia
Leonid G. Voskressensky: Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia

DOI: https://doi.org/10.3390/molecules23113010
Journal volume & issue: Vol. 23, no. 11
p. 3010

Abstract

Read online

1-(p-Methoxyphenyl)tetrazolyl-substituted 6,7-dimethoxy(6,7-methylenedioxy)-1,2,3,4-tetrahydroisoquinolines formed tetrazolyl-substituted azocines in high yields by using activated alkynes. Unsubstituted at 6,7,8-aromatic fragment 1-tetrazolylisoquinoline interacted in several pathways forming tetrazolyl-substituted azocines, 1-tetrazolyl-1-R-vinylisoquinolines and 3-azaspiro[5.5]undeca-1,7,9-triene.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords