Speckle-modulating optical coherence tomography in living mice and humans

Orly Liba; Matthew D. Lew; Elliott D. SoRelle; Rebecca Dutta; Debasish Sen; Darius M. Moshfeghi; Steven Chu; Adam de la Zerda

doi:10.1038/ncomms15845

Nature Communications (Jun 2017)

Speckle-modulating optical coherence tomography in living mice and humans

Orly Liba,
Matthew D. Lew,
Elliott D. SoRelle,
Rebecca Dutta,
Debasish Sen,
Darius M. Moshfeghi,
Steven Chu,
Adam de la Zerda

Affiliations

Orly Liba: Department of Structural Biology, Stanford University
Matthew D. Lew: Department of Structural Biology, Stanford University
Elliott D. SoRelle: Department of Structural Biology, Stanford University
Rebecca Dutta: Department of Structural Biology, Stanford University
Debasish Sen: Department of Structural Biology, Stanford University
Darius M. Moshfeghi: Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine
Steven Chu: The Bio-X Program
Adam de la Zerda: Department of Structural Biology, Stanford University

DOI: https://doi.org/10.1038/ncomms15845
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Optical coherence tomography, a technique that can image inside tissue, is susceptible to speckle noise that limits its diagnostic potential. Here, Libaet al. show that speckle noise can be removed without effectively compromising resolution, revealing previously hidden small structures within tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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