Effect of salivary glands extracts of Hyalomma asiaticum ticks on contractive activity of rat aortic smooth muscle cells

Abstract

Effect of ticks' salivary glands extract on contractive activity of rat aortic smooth muscle cells is studied. Aortic contractions have been induced using hyper- potassium solutions and noradrenaline. Registration of contractive activity of aorta was carried out in isometric regime and the changes were expressed as a percen- tage of the control values. It was determined that the salivary glands extract of ixo- did ticks Hyalomma asiaticum contains components that have a toxic effect on an- imals' body. Relaxant effect of salivary glands extract of Н. asiaticum is caused by its interaction with Са2+-transport systems of smooth muscle cells. Ticks salivary glands extract has an expressed hypotensive effect based on its ability to modify properties of transient receptor potential Са2+-channels of rat aortic smooth muscle cells.

Keywords

• ticks
• salivary gland
• toxins
• extract
• components