Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

Yuxian Guo; Yaru Liu; Shihao Zhao; Wangting Xu; Yiqing Li; Pengwei Zhao; Di Wang; Hongqiang Cheng; Yuehai Ke; Xue Zhang

doi:10.1038/s41467-021-27428-9

Nature Communications (Dec 2021)

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

Yuxian Guo,
Yaru Liu,
Shihao Zhao,
Wangting Xu,
Yiqing Li,
Pengwei Zhao,
Di Wang,
Hongqiang Cheng,
Yuehai Ke,
Xue Zhang

Affiliations

Yuxian Guo: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yaru Liu: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Shihao Zhao: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Wangting Xu: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yiqing Li: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Pengwei Zhao: Department of Biochemistry, Zhejiang University School of Medicine
Di Wang: Institute of Immunology, Zhejiang University School of Medicine
Hongqiang Cheng: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yuehai Ke: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Xue Zhang: Department of Pathology and Pathophysiology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-27428-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Redox-dependent regulation plays a key role in the pathogenesis of acute lung injury, but its mechanism is unclear. Here the authors show Grx1-regulated S-glutathionylation of FABP5 controls macrophage inflammation and alleviates acute lung injury.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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