Nature Communications (Dec 2022)
USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity
- Juan Li,
- Yang Wang,
- Yue Luo,
- Yang Liu,
- Yong Yi,
- Jinsong Li,
- Yang Pan,
- Weiyuxin Li,
- Wanbang You,
- Qingyong Hu,
- Zhiqiang Zhao,
- Yujun Zhang,
- Yang Cao,
- Lingqiang Zhang,
- Junying Yuan,
- Zhi-Xiong Jim Xiao
Affiliations
- Juan Li
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Yang Wang
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Yue Luo
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Yang Liu
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Yong Yi
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Jinsong Li
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Yang Pan
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Weiyuxin Li
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Wanbang You
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Qingyong Hu
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Zhiqiang Zhao
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Yujun Zhang
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Yang Cao
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- Lingqiang Zhang
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Junying Yuan
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Zhi-Xiong Jim Xiao
- Center of Growth, Metabolism and Aging, College of Life Sciences, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-022-35557-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Oncogene-induced senescence (OIS) occurs in premalignant lung adenomas, but infrequently in malignant adenocarcinomas. Here the authors show that USP5-Beclin 1 axis overcomes OIS in Kras-driven lung cancer by enhancing MDM2-mediated p53 degradation.
