Interaction between Mesenchymal Stem Cells and B-Cells

Abstract

Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.

Keywords

• mesenchymal stem cell
• B-cell
• immune regulation
• immune suppression
• systemic lupus erythematous
• graft-versus-host disease
• T-cell
• plasma cell
• cytokine