Frontiers in Genetics (Jun 2013)

Circulating miRNAs: cell-cell communication function?

  • Andrey eTurchinovich,
  • Andrey eTurchinovich,
  • Timur R Samatov,
  • Alexander G Tonevitsky,
  • Alexander G Tonevitsky,
  • Barbara eBurwinkel,
  • Barbara eBurwinkel

DOI
https://doi.org/10.3389/fgene.2013.00119
Journal volume & issue
Vol. 4

Abstract

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Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell-cell signaling function during various physiological and pathological processes. In this review, we discuss the state-of-the-art in the field of intercellular miRNA transport and highlight current theories regarding the origin and the biological function of extracellular miRNAs.

Keywords