1,2-Oxidative Trifluoromethylation of Olefin with Ag(O₂CCF₂SO₂F) and O₂: Synthesis of α-Trifluoromethyl Ketones

Abstract

A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O2CCF2SO2F) as a trifluoromethyl source is described with O2 as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.

Keywords

• Ag(O₂CCF₂SO₂F)
• trifluoromethylation
• α-trifluoromethyl ketones