METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-a]PIRIMIDINIDE l-ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD

A. V. Baklykov; A. A. Tumashov; S. K. Kotovskaya; E. N. Ulomsky; G. L. Rusinov; V. L. Rusinov; G. A. Artem’ev; D. S. Kopchuk; V. N. Charushin

Разработка и регистрация лекарственных средств (Jan 2019)

METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-a]PIRIMIDINIDE l-ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD

A. V. Baklykov,
A. A. Tumashov,
S. K. Kotovskaya,
E. N. Ulomsky,
G. L. Rusinov,
V. L. Rusinov,
G. A. Artem’ev,
D. S. Kopchuk,
V. N. Charushin

Affiliations

A. V. Baklykov: I.Ya. Postovsky Institute of organic synthesis UB of RAS
A. A. Tumashov: I.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
S. K. Kotovskaya: I.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
E. N. Ulomsky: I.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
G. L. Rusinov: I.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
V. L. Rusinov: I.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
G. A. Artem’ev: I.Ya. Postovsky Institute of organic synthesis UB of RAS
D. S. Kopchuk: I.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
V. N. Charushin: I.Ya. Postovsky Institute of organic synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin

Journal volume & issue: Vol. 0, no. 2
pp. 78 – 83

Abstract

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A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18 (EKA, Sweden). The possibility of applying the developed procedure for the technological control of the third stage of the drug «Triazid» preparation was proved by the validation.

Published in Разработка и регистрация лекарственных средств

ISSN: 2305-2066 (Print); 2658-5049 (Online)
Publisher: LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
Country of publisher: Russian Federation
LCC subjects: Social Sciences: Industries. Land use. Labor: Special industries and trades: Pharmaceutical industry
Website: https://www.pharmjournal.ru/

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