A mitochondrial checkpoint to adaptive anticancer immunity

Abstract

ABSTRACTBCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.

Keywords

• Antigen presentation
• CGAS
• immune checkpoint inhibitors
• immunogenic cell death
• mtDNA
• type I interferon