From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents

Abstract

Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.

Keywords

• Antibacterials
• Cyclothialidine
• Dna gyrase inhibitor
• Natural products