Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients

Vidinov K.; Dodova R.; Mitev P.; Mitkova A.; Dimitrova I.; Shinkov A.; Ivanova R.; Mitev V.; Kaneva R.

doi:10.2478/amb-2021-0001

Acta Medica Bulgarica (Apr 2021)

Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients

Vidinov K.,
Dodova R.,
Mitev P.,
Mitkova A.,
Dimitrova I.,
Shinkov A.,
Ivanova R.,
Mitev V.,
Kaneva R.

Affiliations

Vidinov K.: Department of Endocrinology, Medical Faculty, Medical University – Sofia, Bulgaria
Dodova R.: Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University – Sofia, Bulgaria
Mitev P.: Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University – Sofia, Bulgaria
Mitkova A.: Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University – Sofia, Bulgaria
Dimitrova I.: Department of Endocrinology, Medical Faculty, Medical University – Sofia, Bulgaria
Shinkov A.: Department of Endocrinology, Medical Faculty, Medical University – Sofia, Bulgaria
Ivanova R.: Department of Endocrinology, Medical Faculty, Medical University – Sofia, Bulgaria
Mitev V.: Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University – Sofia, Bulgaria
Kaneva R.: Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University – Sofia, Bulgaria

DOI: https://doi.org/10.2478/amb-2021-0001
Journal volume & issue: Vol. 48, no. 1
pp. 1 – 8

Abstract

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Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development. Very little research has been done on their frequency and clinical relevance in Bulgarian patients with papillary thyroid cancer (PTC). This study is focused on investigating somatic mutation frequency in Bulgarian patients with PTC and their association with clinicopathologic features.

Published in Acta Medica Bulgarica

ISSN: 0324-1750 (Print); 2719-5384 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine
Website: https://sciendo.com/journal/AMB

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Abstract

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