Journal of Clinical and Translational Endocrinology Case Reports (Mar 2025)

Severe hepatopulmonary syndrome with end-stage liver cirrhosis associated with pan-hypopituitarism in a pediatric patient

  • Shawn A. Haupt,
  • Jessica C. Chang,
  • Roya Zarpak,
  • Arash R. Zandieh,
  • Nada A. Yazigi,
  • Udeme D. Ekong,
  • Juan F. Guerra,
  • Thomas M. Fishbein,
  • Cal S. Matsumoto,
  • Alexander H. Kroemer,
  • Khalid M. Khan

Journal volume & issue
Vol. 35
p. 100179

Abstract

Read online

Cholestasis in the neonatal period requires a prompt and thorough evaluation. Panhypopituitarism is an uncommon but known cause of cholestasis. Here we present a rare and late complication of liver disease secondary to congenital hypopituitarism. Pediatric patients presenting with cholestasis and other manifestations of pituitary malfunction warrant further evaluation.

Keywords