Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in multimodal therapy for patients with oligometastatic peritoneal gastric cancer: a randomized multicenter phase III trial PIPAC VEROne

Casella Francesco; Bencivenga Maria; Rosati Riccardo; Fumagalli Uberto Romario; Marrelli Daniele; Pacelli Fabio; Macrì Antonio; Donini Annibale; Torroni Lorena; Pavarana Michele; De Manzoni Giovanni

doi:10.1515/pp-2022-0111

Pleura and Peritoneum (Jun 2022)

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in multimodal therapy for patients with oligometastatic peritoneal gastric cancer: a randomized multicenter phase III trial PIPAC VEROne

Casella Francesco,
Bencivenga Maria,
Rosati Riccardo,
Fumagalli Uberto Romario,
Marrelli Daniele,
Pacelli Fabio,
Macrì Antonio,
Donini Annibale,
Torroni Lorena,
Pavarana Michele,
De Manzoni Giovanni

Affiliations

Casella Francesco: Department and of Surgical, General and Upper GI Surgery Division, Odontostomatologic, Maternal and Child Sciences, University of Verona, Verona, Italy
Bencivenga Maria: Department and of Surgical, General and Upper GI Surgery Division, Odontostomatologic, Maternal and Child Sciences, University of Verona, Verona, Italy
Rosati Riccardo: Department of Surgery, San Raffaele Hospital, San Raffaele Vita-salute University, Milan, Italy
Fumagalli Uberto Romario: Digestive Surgery, European Institute of Oncology, Milan, Italy
Marrelli Daniele: Department of Surgery, Siena University Hospital, University of Siena, Siena, Italy
Pacelli Fabio: Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy
Macrì Antonio: Peritoneal Surface Malignancy and Soft Tissue Sarcoma Program, University of Messina, Messina, Italy
Donini Annibale: General and Emergency Surgery, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy
Torroni Lorena: Department of Diagnostic and Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy
Pavarana Michele: Department of Oncology, University of Verona, Verona, Italy
De Manzoni Giovanni: Department and of Surgical, General and Upper GI Surgery Division, Odontostomatologic, Maternal and Child Sciences, University of Verona, Verona, Italy

DOI: https://doi.org/10.1515/pp-2022-0111
Journal volume & issue: Vol. 7, no. 3
pp. 135 – 141

Abstract

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Peritoneal carcinomatosis is the most frequent site of metastases in patients with gastric cancer. Current standard treatment is palliative systemic chemotherapy with very poor prognosis. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) resulted in long-term benefits in selected patients. Among patients with peritoneal carcinomatosis, a distinctive subset is oligometastatic disease which is characterized by low metastatic burden. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a recent technique of intraperitoneal chemotherapy used in combination with systemic chemotherapy with promising results.

Published in Pleura and Peritoneum

ISSN: 2364-768X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.degruyter.com/view/journals/pp/pp-overview.xml

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