Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34
<sup>+</sup>
Hematopoietic Progenitor Cells from Apoptosis

Meaghan H. Hancock; Lindsey B. Crawford; Wilma Perez; Hillary M. Struthers; Jennifer Mitchell; Patrizia Caposio

doi:10.1128/mSphere.00986-20

mSphere (Feb 2021)

Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34 <sup>+</sup> Hematopoietic Progenitor Cells from Apoptosis

Meaghan H. Hancock,
Lindsey B. Crawford,
Wilma Perez,
Hillary M. Struthers,
Jennifer Mitchell,
Patrizia Caposio

Affiliations

Meaghan H. Hancock: ORCiD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA
Lindsey B. Crawford: ORCiD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA
Wilma Perez: Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA
Hillary M. Struthers: Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA
Jennifer Mitchell: Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA
Patrizia Caposio: ORCiD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA

DOI: https://doi.org/10.1128/mSphere.00986-20
Journal volume & issue: Vol. 6, no. 1

Abstract

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Human cytomegalovirus (HCMV) causes serious disease in immunocompromised individuals and is a significant problem during transplantation. The virus can establish a latent infection in CD34 +

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

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