A single transcription factor facilitates an insect host combating Bacillus thuringiensis infection while maintaining fitness

Zhaojiang Guo; Le Guo; Jianying Qin; Fan Ye; Dan Sun; Qingjun Wu; Shaoli Wang; Neil Crickmore; Xuguo Zhou; Alejandra Bravo; Mario Soberón; Youjun Zhang

doi:10.1038/s41467-022-33706-x

Nature Communications (Oct 2022)

A single transcription factor facilitates an insect host combating Bacillus thuringiensis infection while maintaining fitness

Zhaojiang Guo,
Le Guo,
Jianying Qin,
Fan Ye,
Dan Sun,
Qingjun Wu,
Shaoli Wang,
Neil Crickmore,
Xuguo Zhou,
Alejandra Bravo,
Mario Soberón,
Youjun Zhang

Affiliations

Zhaojiang Guo: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences
Le Guo: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences
Jianying Qin: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences
Fan Ye: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences
Dan Sun: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences
Qingjun Wu: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences
Shaoli Wang: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences
Neil Crickmore: School of Life Sciences, University of Sussex
Xuguo Zhou: Department of Entomology, University of Kentucky
Alejandra Bravo: Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México
Mario Soberón: Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México
Youjun Zhang: Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences

DOI: https://doi.org/10.1038/s41467-022-33706-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Plutella xylostella endures Bt toxins with no performance costs. This study reveals how, depending on the presence of the toxin, this insect modifies MAPK phosphorylation to modulate the transcription factor FTZ-F1 binding, to up- or down- regulate Bt receptors or non-receptor (resistant) paralogs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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