Nature Communications (Aug 2020)
Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
- Yura Grabovska,
- Alan Mackay,
- Patricia O’Hare,
- Stephen Crosier,
- Martina Finetti,
- Edward C. Schwalbe,
- Jessica C. Pickles,
- Amy R. Fairchild,
- Aimee Avery,
- Julia Cockle,
- Rebecca Hill,
- Janet Lindsey,
- Debbie Hicks,
- Mark Kristiansen,
- Jane Chalker,
- John Anderson,
- Darren Hargrave,
- Thomas S. Jacques,
- Karin Straathof,
- Simon Bailey,
- Chris Jones,
- Steven C. Clifford,
- Daniel Williamson
Affiliations
- Yura Grabovska
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Alan Mackay
- Division of Molecular Pathology and Division of Cancer Therapeutics, The Institute of Cancer Research
- Patricia O’Hare
- Department of Paediatric Oncology, Great Ormond Street Hospital NHS Trust
- Stephen Crosier
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Martina Finetti
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Edward C. Schwalbe
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Jessica C. Pickles
- Developmental Biology and Cancer Programme, University College London Great Ormond Street Institute of Child Health
- Amy R. Fairchild
- Developmental Biology and Cancer Programme, University College London Great Ormond Street Institute of Child Health
- Aimee Avery
- Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust
- Julia Cockle
- Division of Molecular Pathology and Division of Cancer Therapeutics, The Institute of Cancer Research
- Rebecca Hill
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Janet Lindsey
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Debbie Hicks
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Mark Kristiansen
- UCL Genomics, UCL Great Ormond Street Institute of Child Health
- Jane Chalker
- Specialist Integrated Haematology and Malignancy Diagnostic Service-Acquired Genomics, Great Ormond Street Hospital for Children NHS Foundation Trust
- John Anderson
- Department of Paediatric Oncology, Great Ormond Street Hospital NHS Trust
- Darren Hargrave
- Department of Paediatric Oncology, Great Ormond Street Hospital NHS Trust
- Thomas S. Jacques
- Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust
- Karin Straathof
- Department of Paediatric Oncology, Great Ormond Street Hospital NHS Trust
- Simon Bailey
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Chris Jones
- Division of Molecular Pathology and Division of Cancer Therapeutics, The Institute of Cancer Research
- Steven C. Clifford
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- Daniel Williamson
- Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
- DOI
- https://doi.org/10.1038/s41467-020-18070-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling may inform immunotherapy approaches in paediatric patients with CNS tumour.
