Nature Communications (Apr 2018)

Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells

  • Xiaojie Ma,
  • Xi Chen,
  • Yan Jin,
  • Wenyan Ge,
  • Weiyun Wang,
  • Linghao Kong,
  • Junfang Ji,
  • Xing Guo,
  • Jun Huang,
  • Xin-Hua Feng,
  • Junfen Fu,
  • Saiyong Zhu

DOI
https://doi.org/10.1038/s41467-018-03760-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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Precise genome editing in human pluripotent stem cells requires the development of methods for rapid and efficient genetic manipulation. Here, the authors screen for small molecules that enhance CRISPR-Cpf1-mediated genome engineering.