Research Results in Pharmacology (Mar 2016)

DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

  • Andrey Buzov,
  • Alexandr Kulikov,
  • Tatyana Avtina,
  • Mikhail Pokrovskii,
  • Ol'ga Osipova

DOI
https://doi.org/10.18413/2313-8971-2016-2-1-52-57
Journal volume & issue
Vol. 2, no. 1
pp. 52 – 57

Abstract

Read online Read online Read online

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.

Keywords