Nature Communications (Jan 2018)
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
- Tuoyi Li,
- Bing Yu,
- Zhixin Liu,
- Jingyuan Li,
- Mingliang Ma,
- Yingbao Wang,
- Mingjiang Zhu,
- Huiyong Yin,
- Xiaofeng Wang,
- Yi Fu,
- Fang Yu,
- Xian Wang,
- Xiaohong Fang,
- Jinpeng Sun,
- Wei Kong
Affiliations
- Tuoyi Li
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education
- Bing Yu
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education
- Zhixin Liu
- Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University; Key Laboratory Experimental Teratology of the Ministry of Education
- Jingyuan Li
- CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics
- Mingliang Ma
- Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University; Key Laboratory Experimental Teratology of the Ministry of Education
- Yingbao Wang
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education
- Mingjiang Zhu
- Key Laboratory of Food Safety Research, Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Huiyong Yin
- Key Laboratory of Food Safety Research, Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Xiaofeng Wang
- CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics
- Yi Fu
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education
- Fang Yu
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education
- Xian Wang
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education
- Xiaohong Fang
- Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences
- Jinpeng Sun
- Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University; Key Laboratory Experimental Teratology of the Ministry of Education
- Wei Kong
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education
- DOI
- https://doi.org/10.1038/s41467-017-02401-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
High homocysteine plasma levels are associated with cardiovascular diseases. Here, Li and colleagues find that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vascular effects of hyperhomocysteinemia.
