模式生物斑马鱼在卒中研究中的应用Application of Zebrafish Model Organism in Stroke Research

Abstract

Animal model provides a necessary tool for exploring the complex pathophysiological process of cerebrovascular disease and drug development. Zebrafish (Danio rerio) is an ideal spinal model organism, which has the characteristics of small size, strong reproductive capacity, good visibility, short experimental period, and low cost. In addition, the genetic sequence of zebrafish is highly similar to human. It has its own unique advantages in living vascular research, and has been more and more used in stroke research. This paper introduced the characteristics of zebrafish model and its application in stroke research, to provide some help for the follow-up research. 动物模型为探索脑血管疾病的病理生理演变及药物研发提供了必要工具。斑马鱼（zebrafish，Danio rerio）是一种理想的脊椎模式生物，具有体型小、繁殖能力强、可视性好、实验周期短、成本低、遗传序列与人类高度相近等特点，在活体血管研究方面具备自身独特的优势，已被越来越多地应用于卒中相关的研究当中。本文概括介绍了斑马鱼模型的特点及其在卒中研究中的应用现状，以期为后续的研究提供一定的帮助。本文通过总结归纳斑马鱼相对于传统模式生物在体型、繁殖能力、成本上的优势，以及血管可视性佳、遗传序列与人类高度相近、药物筛选便捷等特点,为卒中领域研究者在模型构建与模式生物的选用上提供了参考。

Keywords

• 马鱼
• 模式生物
• 脑血管疾病
• 卒中
• zebrafish
• model organism
• cerebrovascular disease
• stroke