Nature Communications (Jul 2019)
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
- Joshua D. Ooi,
- Jhih-Hang Jiang,
- Peter J. Eggenhuizen,
- Ling L. Chua,
- Mirjan van Timmeren,
- Khai L. Loh,
- Kim M. O’Sullivan,
- Poh Y. Gan,
- Yong Zhong,
- Kirill Tsyganov,
- Lani R. Shochet,
- Jessica Ryan,
- Coen A. Stegeman,
- Lars Fugger,
- Hugh H. Reid,
- Jamie Rossjohn,
- Peter Heeringa,
- Stephen R. Holdsworth,
- Anton Y. Peleg,
- A. Richard Kitching
Affiliations
- Joshua D. Ooi
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Jhih-Hang Jiang
- Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
- Peter J. Eggenhuizen
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Ling L. Chua
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Mirjan van Timmeren
- Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen
- Khai L. Loh
- Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Kim M. O’Sullivan
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Poh Y. Gan
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Yong Zhong
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Kirill Tsyganov
- Monash Bioinformatics Platform, Monash University
- Lani R. Shochet
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Jessica Ryan
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Coen A. Stegeman
- Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen
- Lars Fugger
- Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Hugh H. Reid
- Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Jamie Rossjohn
- Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Peter Heeringa
- Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen
- Stephen R. Holdsworth
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- Anton Y. Peleg
- Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
- A. Richard Kitching
- Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre
- DOI
- https://doi.org/10.1038/s41467-019-11255-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.
