Nature Communications (Feb 2022)
Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism
- Binyamin Duethorn,
- Fabian Groll,
- Bettina Rieger,
- Hannes C. A. Drexler,
- Heike Brinkmann,
- Ludmila Kremer,
- Martin Stehling,
- Marie-Theres Borowski,
- Karina Mildner,
- Dagmar Zeuschner,
- Magdalena Zernicka-Goetz,
- Marc P. Stemmler,
- Karin B. Busch,
- Juan M. Vaquerizas,
- Ivan Bedzhov
Affiliations
- Binyamin Duethorn
- Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine
- Fabian Groll
- Regulatory Genomics group, Max Planck Institute for Molecular Biomedicine
- Bettina Rieger
- Institut für Integrative Zellbiologie und Physiologie, University of Münster
- Hannes C. A. Drexler
- Mass Spectrometry Unit, Max Planck Institute for Molecular Biomedicine
- Heike Brinkmann
- Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine
- Ludmila Kremer
- Transgenic Facility, Max Planck Institute for Molecular Biomedicine
- Martin Stehling
- Flow Cytometry Unit, Max Planck Institute for Molecular Biomedicine
- Marie-Theres Borowski
- Institut für Integrative Zellbiologie und Physiologie, University of Münster
- Karina Mildner
- Electron Microscopy Facility, Max Planck Institute for Molecular Biomedicine
- Dagmar Zeuschner
- Electron Microscopy Facility, Max Planck Institute for Molecular Biomedicine
- Magdalena Zernicka-Goetz
- Mammalian Embryo and Stem Cell Group, Department of Physiology, Development, and Neuroscience, University of Cambridge
- Marc P. Stemmler
- Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, FAU University Erlangen-Nürnberg
- Karin B. Busch
- Institut für Integrative Zellbiologie und Physiologie, University of Münster
- Juan M. Vaquerizas
- Regulatory Genomics group, Max Planck Institute for Molecular Biomedicine
- Ivan Bedzhov
- Embryonic Self-Organization research group, Max Planck Institute for Molecular Biomedicine
- DOI
- https://doi.org/10.1038/s41467-022-28139-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
How pluripotency transcription factors regulate the cellular architecture and energetics has remained largely unknown. Here the authors identify Lima1 as a key effector that mediates the pluripotency control of membrane dynamics and cellular metabolism.
