PLoS ONE (Jan 2021)

Differences in the characteristics and contemporary cardiac outcomes of patients with light-chain versus transthyretin cardiac amyloidosis.

  • Osnat Itzhaki Ben Zadok,
  • Mordehay Vaturi,
  • Iuliana Vaxman,
  • Zaza Iakobishvili,
  • Noa Rhurman-Shahar,
  • Ran Kornowski,
  • Ashraf Hamdan

DOI
https://doi.org/10.1371/journal.pone.0255487
Journal volume & issue
Vol. 16, no. 8
p. e0255487

Abstract

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AimsTo compare the baseline cardiovascular characteristics of immunoglobulin light-chain (AL) and amyloid transthyretin (ATTR) cardiac amyloidosis (CA) and to investigate patients' contemporary cardiac outcomes.MethodsSingle-center analysis of clinical, laboratory, echocardiographic and cardiac magnetic resonance imaging (CMRi) characteristics of AL and ATTR-CA patients' cohort (years 2013-2020).ResultsIncluded were 67 CA patients of whom 31 (46%) had AL-CA and 36 (54%) had ATTR-CA. Patients with ATTR-CA versus AL-CA were older (80 (IQR 70, 85) years versus 65 (IQR 60, 71) years, respectively, pConclusionDespite the various similarities of AL-CA and ATTR-CA, these diseases have distinct baseline cardiovascular profiles and different heart failure course, thus merit tailored-cardiac management.