Application of Inorganic Nanocomposite Hydrogels in Bone Tissue Engineering

Xiaying Han; Houshi Xu; Lingbin Che; Dongyong Sha; Chaojun Huang; Tong Meng; Dianwen Song

iScience (Dec 2020)

Application of Inorganic Nanocomposite Hydrogels in Bone Tissue Engineering

Xiaying Han,
Houshi Xu,
Lingbin Che,
Dongyong Sha,
Chaojun Huang,
Tong Meng,
Dianwen Song

Affiliations

Xiaying Han: Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Shanghai 200080, China
Houshi Xu: Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Lingbin Che: Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Shanghai 200080, China
Dongyong Sha: Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, P.R. China
Chaojun Huang: Department of Orthopedics, Shanghai General Hospital, Nanjing Medical University, Shanghai 200080, China
Tong Meng: Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Shanghai 200080, China; Corresponding author
Dianwen Song: Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Shanghai 200080, China; Corresponding author

Journal volume & issue: Vol. 23, no. 12
p. 101845

Abstract

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Summary: Bone defects caused by trauma and surgery are common clinical problems encountered by orthopedic surgeons. Thus, a hard-textured, natural-like biomaterial that enables encapsulated cells to obtain the much-needed biophysical stimulation and produce functional bone tissue is needed. Incorporating nanomaterials into cell-laden hydrogels is a straightforward tactic for producing tissue engineering structures that integrate perfectly with the body and for tailoring the material characteristics of hydrogels without hindering nutrient exchange with the surroundings. In this review, recent developments in inorganic nanocomposite hydrogels for bone tissue engineering that are of vital importance but have not yet been comprehensively reviewed are summarized.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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