Sleep Science ()

<i>APOE</i> Polymorphism, Obstructive Sleep Apnea, and Cognitive Function

  • Elisangela Macedo Gara,
  • Thiago Tanaka Goya,
  • Rosyvaldo Ferreira-Silva,
  • Larissa Matheus,
  • Renato Marques Jordão,
  • Marlon Lemos Araújo,
  • Alanna Joselle Silva,
  • Renan Segalla Guerra,
  • Geraldo Lorenzi-Filho,
  • Linda Massako Ueno-Pardi

DOI
https://doi.org/10.1055/s-0044-1788286

Abstract

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Objective Obstructive sleep apnea (OSA) is associated with the apolipoprotein E ε4 polymorphic allele (APOE ε4) and with worse cognitive function. However, the influence of APOE ε4 on cognitive function in patients with moderate-to-severe OSA is controversial. The present study evaluated the influence of APOE ε4 polymorphism and cognitive function in sedentary OSA patients with no other major comorbidities.

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