CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

Mario Bunse; Janina Pfeilschifter; Julia Bluhm; Maria Zschummel; Jara J. Joedicke; Anthea Wirges; Helen Stark; Vivien Kretschmer; Markus Chmielewski; Wolfgang Uckert; Hinrich Abken; Jörg Westermann; Armin Rehm; Uta E. Höpken

doi:10.1038/s41467-020-20488-3

Nature Communications (Jan 2021)

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

Mario Bunse,
Janina Pfeilschifter,
Julia Bluhm,
Maria Zschummel,
Jara J. Joedicke,
Anthea Wirges,
Helen Stark,
Vivien Kretschmer,
Markus Chmielewski,
Wolfgang Uckert,
Hinrich Abken,
Jörg Westermann,
Armin Rehm,
Uta E. Höpken

Affiliations

Mario Bunse: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Microenvironmental Regulation in Autoimmunity and Cancer
Janina Pfeilschifter: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Microenvironmental Regulation in Autoimmunity and Cancer
Julia Bluhm: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Translational Tumorimmunology
Maria Zschummel: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Microenvironmental Regulation in Autoimmunity and Cancer
Jara J. Joedicke: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Microenvironmental Regulation in Autoimmunity and Cancer
Anthea Wirges: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Translational Tumorimmunology
Helen Stark: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Translational Tumorimmunology
Vivien Kretschmer: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Microenvironmental Regulation in Autoimmunity and Cancer
Markus Chmielewski: Department I of Internal Medicine, University Hospital Cologne
Wolfgang Uckert: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Molecular Cell Biology and Gene Therapy
Hinrich Abken: RCI Regensburg Center for Interventional Immunology, Department Genetic Immunotherapy, University Hospital Regensburg
Jörg Westermann: Department of Hematology, Oncology and Tumorimmunology
Armin Rehm: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Translational Tumorimmunology
Uta E. Höpken: Max-Delbrück-Center for Molecular Medicine, MDC, Department of Microenvironmental Regulation in Autoimmunity and Cancer

DOI: https://doi.org/10.1038/s41467-020-20488-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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CAR-T cell therapy targeting CD19 is not as efficient to treat lymphoma with nodal dissemination as it is for B cell leukaemia. Here, the authors generate CAR-T cells against CXCR5 and show they inhibit tumour growth by depleting both B and follicular T helper cells in lymphoma models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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