Balkan Medical Journal (Jun 2011)

Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch

  • Tülay Kılıçaslan Ayna,
  • Hilmi Tozkır,
  • Hayriye Şentürk Çiftçi,
  • Hakan Gürkan,
  • Emre Tekgündüz,
  • Çetin Algüneş,
  • Mehmet Gürtekin,
  • Mahmut Çarin

Journal volume & issue
Vol. 28, no. 02
pp. 224 – 226

Abstract

Read online

Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DQ but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.

Keywords