Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Akihisa Kato; Shungo Adachi; Shuichi Kawano; Kousuke Takeshima; Mizuki Watanabe; Shinobu Kitazume; Ryota Sato; Hideo Kusano; Naoto Koyanagi; Yuhei Maruzuru; Jun Arii; Tomohisa Hatta; Tohru Natsume; Yasushi Kawaguchi

doi:10.1038/s41467-020-18718-9

Nature Communications (Sep 2020)

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Akihisa Kato,
Shungo Adachi,
Shuichi Kawano,
Kousuke Takeshima,
Mizuki Watanabe,
Shinobu Kitazume,
Ryota Sato,
Hideo Kusano,
Naoto Koyanagi,
Yuhei Maruzuru,
Jun Arii,
Tomohisa Hatta,
Tohru Natsume,
Yasushi Kawaguchi

Affiliations

Akihisa Kato: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Shungo Adachi: Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)
Shuichi Kawano: Department of Computer and Network Engineering, Graduate School of Informatics and Engineering, The University of Electro-Communications
Kousuke Takeshima: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Mizuki Watanabe: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Shinobu Kitazume: Preparing Section for New Faculty of Medical Science, Fukushima Medical University, Fukushima City
Ryota Sato: Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Hideo Kusano: Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)
Naoto Koyanagi: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Yuhei Maruzuru: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Jun Arii: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Tomohisa Hatta: Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)
Tohru Natsume: Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)
Yasushi Kawaguchi: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-020-18718-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

Read online

Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal