Tropical Medicine and Infectious Disease (Jul 2022)

Fibrinogen-to-Albumin Ratio and Blood Urea Nitrogen-to-Albumin Ratio in COVID-19 Patients: A Systematic Review and Meta-Analysis

  • Juan R. Ulloque-Badaracco,
  • Esteban A. Alarcon-Braga,
  • Enrique A. Hernandez-Bustamante,
  • Ali Al-kassab-Córdova,
  • Melany D. Mosquera-Rojas,
  • Ricardo R. Ulloque-Badaracco,
  • Miguel A. Huayta-Cortez,
  • Sherelym H. Maita-Arauco,
  • Percy Herrera-Añazco,
  • Vicente A. Benites-Zapata

DOI
https://doi.org/10.3390/tropicalmed7080150
Journal volume & issue
Vol. 7, no. 8
p. 150

Abstract

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Fibrinogen-to-albumin ratio (FAR) and blood urea nitrogen-to-albumin ratio (BAR) are inflammatory biomarkers that have been associated with clinical outcomes of multiple diseases. The objective of this study is to evaluate the association of these biomarkers with the severity and mortality of COVID-19 patients. A systematic search was performed in five databases. Observational studies that reported the association between FAR and BAR values with the severity and mortality of COVID-19 patients were included. Random-effects models were used for meta-analyses, and effects were expressed as Odds Ratio (OR) and their 95% confidence intervals (CI). Publication bias was assessed using the Begg test, while the quality assessment was assessed using the Newcastle Ottawa Scale. A total of 21 studies (n = 7949) were included. High FAR values were associated with a higher risk of severity (OR: 2.41; 95% CI 1.41–4.12; p p p p = 0.38). High FAR and BAR values were associated with poor clinical outcomes.

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