BMC Gastroenterology (Sep 2010)

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

  • Engel Christoph,
  • Kloor Matthias,
  • Betz Beate,
  • Kötting Judith,
  • Görgens Heike,
  • Schackert Hans K,
  • Morak Monika,
  • Holinski-Feder Elke,
  • Rahner Nils,
  • Steinke Verena,
  • Novotny Jan,
  • Vodickova Ludmila,
  • Naccarati Alessio,
  • Pardini Barbara,
  • Campa Daniele,
  • Büttner Reinhard,
  • Propping Peter,
  • Försti Asta,
  • Hemminki Kari,
  • Barale Roberto,
  • Vodicka Pavel,
  • Canzian Federico

DOI
https://doi.org/10.1186/1471-230X-10-112
Journal volume & issue
Vol. 10, no. 1
p. 112

Abstract

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Abstract Background Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Methods We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic. Results We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany. Conclusion A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).