Nature Communications (Nov 2021)
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
- Nikolas Friedrich,
- Emanuel Stiegeler,
- Matthias Glögl,
- Thomas Lemmin,
- Simon Hansen,
- Claus Kadelka,
- Yufan Wu,
- Patrick Ernst,
- Liridona Maliqi,
- Caio Foulkes,
- Mylène Morin,
- Mustafa Eroglu,
- Thomas Liechti,
- Branislav Ivan,
- Thomas Reinberg,
- Jonas V. Schaefer,
- Umut Karakus,
- Stephan Ursprung,
- Axel Mann,
- Peter Rusert,
- Roger D. Kouyos,
- John A. Robinson,
- Huldrych F. Günthard,
- Andreas Plückthun,
- Alexandra Trkola
Affiliations
- Nikolas Friedrich
- Institute of Medical Virology, University of Zurich (UZH)
- Emanuel Stiegeler
- Institute of Medical Virology, University of Zurich (UZH)
- Matthias Glögl
- Institute of Medical Virology, University of Zurich (UZH)
- Thomas Lemmin
- Institute of Medical Virology, University of Zurich (UZH)
- Simon Hansen
- Department of Biochemistry, University of Zurich (UZH)
- Claus Kadelka
- Department of Mathematics, Iowa State University
- Yufan Wu
- Department of Biochemistry, University of Zurich (UZH)
- Patrick Ernst
- Department of Biochemistry, University of Zurich (UZH)
- Liridona Maliqi
- Institute of Medical Virology, University of Zurich (UZH)
- Caio Foulkes
- Institute of Medical Virology, University of Zurich (UZH)
- Mylène Morin
- Department of Chemistry, University of Zurich (UZH)
- Mustafa Eroglu
- Institute of Medical Virology, University of Zurich (UZH)
- Thomas Liechti
- Institute of Medical Virology, University of Zurich (UZH)
- Branislav Ivan
- Institute of Medical Virology, University of Zurich (UZH)
- Thomas Reinberg
- Department of Biochemistry, University of Zurich (UZH)
- Jonas V. Schaefer
- Department of Biochemistry, University of Zurich (UZH)
- Umut Karakus
- Institute of Medical Virology, University of Zurich (UZH)
- Stephan Ursprung
- Institute of Medical Virology, University of Zurich (UZH)
- Axel Mann
- Institute of Medical Virology, University of Zurich (UZH)
- Peter Rusert
- Institute of Medical Virology, University of Zurich (UZH)
- Roger D. Kouyos
- Institute of Medical Virology, University of Zurich (UZH)
- John A. Robinson
- Department of Chemistry, University of Zurich (UZH)
- Huldrych F. Günthard
- Institute of Medical Virology, University of Zurich (UZH)
- Andreas Plückthun
- Department of Biochemistry, University of Zurich (UZH)
- Alexandra Trkola
- Institute of Medical Virology, University of Zurich (UZH)
- DOI
- https://doi.org/10.1038/s41467-021-27075-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles CCR5- bound V3.
