Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

Zixiang Wang; Shourong Wang; Junchao Qin; Xiyu Zhang; Gang Lu; Hongbin Liu; Haiyang Guo; Ligang Wu; Victoria O. Shender; Changshun Shao; Beihua Kong; Zhaojian Liu

doi:10.1038/s41467-022-34042-w

Nature Communications (Oct 2022)

Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

Zixiang Wang,
Shourong Wang,
Junchao Qin,
Xiyu Zhang,
Gang Lu,
Hongbin Liu,
Haiyang Guo,
Ligang Wu,
Victoria O. Shender,
Changshun Shao,
Beihua Kong,
Zhaojian Liu

Affiliations

Zixiang Wang: Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Science, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
Shourong Wang: Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Science, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
Junchao Qin: Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Science, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
Xiyu Zhang: Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Science, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
Gang Lu: CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong
Hongbin Liu: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University
Haiyang Guo: Department of Clinical Laboratory, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University
Ligang Wu: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Victoria O. Shender: Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
Changshun Shao: Institutes for Translational Medicine, Soochow University
Beihua Kong: Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Science, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
Zhaojian Liu: Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Science, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University

DOI: https://doi.org/10.1038/s41467-022-34042-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Altered expression of splicing factors can contribute to tumour progression. Here the authors show that splicing factor BUD31 enhances ovarian cancer progression by promoting exon inclusion in the anti-apoptotic BCL2 family member, BCL2L12.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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