N'-(2-Hydroxybenzylidene)-3-methylbenzohydrazide and Its Copper(II) Complex: Syntheses, Characterization, Crystal Structures and Biological Activity

Abstract

The hydrazone compound N'-(2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L) was prepared. With H2L and copper acetate a new copper complex [Cu(HL)(NCS)]·CH3OH was synthesized. Both the hydrazone and the copper complex were characterized by physico-chemical methods and single crystal X-ray diffraction techniques. The complex is a thiocyanato-coordinated copper(II) species. The Cu atom in the complex is in square planar geometry. The complex is a promising urease inhibitor.

Keywords

• hydrazone
• copper complex
• crystal structure
• biological activity