A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

Michael J. Maxwell; Chris Thekkedam; Cedric Lamboley; Yanni K.-Y. Chin; Theo Crawford; Jennifer J. Smith; Junyu Liu; Xinying Jia; Irina Vetter; Derek R. Laver; Bradley S. Launikonis; Angela Dulhunty; Eivind A. B. Undheim; Mehdi Mobli

doi:10.1038/s41467-023-36579-w

Nature Communications (Feb 2023)

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

Michael J. Maxwell,
Chris Thekkedam,
Cedric Lamboley,
Yanni K.-Y. Chin,
Theo Crawford,
Jennifer J. Smith,
Junyu Liu,
Xinying Jia,
Irina Vetter,
Derek R. Laver,
Bradley S. Launikonis,
Angela Dulhunty,
Eivind A. B. Undheim,
Mehdi Mobli

Affiliations

Michael J. Maxwell: Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Chris Thekkedam: Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University
Cedric Lamboley: School of Biomedical Sciences, The University of Queensland
Yanni K.-Y. Chin: Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Theo Crawford: Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Jennifer J. Smith: Institute for Molecular Bioscience, The University of Queensland
Junyu Liu: Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Xinying Jia: Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Irina Vetter: Institute for Molecular Bioscience, The University of Queensland
Derek R. Laver: School of Biomedical Sciences and Pharmacy, University of Newcastle
Bradley S. Launikonis: School of Biomedical Sciences, The University of Queensland
Angela Dulhunty: Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University
Eivind A. B. Undheim: Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Mehdi Mobli: Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland

DOI: https://doi.org/10.1038/s41467-023-36579-w
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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Insect toxins with tandem repeats of neurotoxin domains have been found with enhanced receptor avidity. Here, the authors describe a bivalent toxin from remipede venom that targets ryanodine receptors, a rare target for animal venoms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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