Nature Communications (Dec 2021)

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

  • Wen Hao Neo,
  • Yiran Meng,
  • Alba Rodriguez-Meira,
  • Muhammad Z. H. Fadlullah,
  • Christopher A. G. Booth,
  • Emanuele Azzoni,
  • Supat Thongjuea,
  • Marella F. T. R. de Bruijn,
  • Sten Eirik W. Jacobsen,
  • Adam J. Mead,
  • Georges Lacaud

DOI
https://doi.org/10.1038/s41467-021-27140-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Yolk sac erythro-myeloid progenitors (EMPs) are critical for embryo viability and a major source of adult tissue-resident macrophages. Here, the authors show an essential stage-specific role for Ezh2 in modulating Wnt signaling during EMP generation.