Nature Communications (Dec 2021)
Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
Abstract
Yolk sac erythro-myeloid progenitors (EMPs) are critical for embryo viability and a major source of adult tissue-resident macrophages. Here, the authors show an essential stage-specific role for Ezh2 in modulating Wnt signaling during EMP generation.