EFFECT OF SIMVASTATIN THERAPY UPON IMMUNOLOGICAL MARKERS OF ATHEROSCLEROSIS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS

Abstract

Аbstract. The study concerned in vitro effects of mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra upon antigen-induced activation of EBV-speciлc CD4+T-cells from peripheral blood of the patients with rheumatoid arthritis (RA). RA patients were shown to have signiлcantly lower contents of antigen-activated, EBV-speciлc CD4+T-cells than healthy donors. In healthy controls, mevastatin, in”iximab, r-met-Hu-sTNF-RI and IL-1Ra did not cause sufлcient changes in concentrations of CD4+, IFN-γ+ cells. Likewise, there was no detectable in”uence of the abovementioned drugs upon the numbers of RA EBV-speciлc CD4+ , IFNγ+ cells. Thus, in RA patients, the antigen-induced activation of EBVspeciлc CD4+T-cells is reduced. Meanwhile, in vitro supplement with statins and the mentioned biological agents did not promote further suppression of this cell activity. (Med. Immunol., 2011, vol. 13, N 1, pp 101-104)

Keywords

• rheumatoid arthritis
• atherosclerosis
• immunological markers
• treatment
• statins