The First Case Report of Effective Treatment With Sotorasib for Metastatic Atypical Lung Carcinoid Harboring KRAS G12C Mutation and Aggressive Disseminated Lung Metastasis: A Case Report

Masafumi Saiki, MD; Chisa Omori, MD; Honami Morikawa, MD; Ken Shinohara, MD; So Shimamura, MD; Hiroki Ohkoshi, MD; Yoshinori Uchida, MD; Tomohiro Inoue, MD, PhD; Tetsuo Kondo, MD, PhD; Shinnosuke Ikemura, MD, PhD; Kenzo Soejima, MD, PhD

JTO Clinical and Research Reports (Jan 2024)

The First Case Report of Effective Treatment With Sotorasib for Metastatic Atypical Lung Carcinoid Harboring KRAS G12C Mutation and Aggressive Disseminated Lung Metastasis: A Case Report

Masafumi Saiki, MD,
Chisa Omori, MD,
Honami Morikawa, MD,
Ken Shinohara, MD,
So Shimamura, MD,
Hiroki Ohkoshi, MD,
Yoshinori Uchida, MD,
Tomohiro Inoue, MD, PhD,
Tetsuo Kondo, MD, PhD,
Shinnosuke Ikemura, MD, PhD,
Kenzo Soejima, MD, PhD

Affiliations

Masafumi Saiki, MD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Chisa Omori, MD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Honami Morikawa, MD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Ken Shinohara, MD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan
So Shimamura, MD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Hiroki Ohkoshi, MD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Yoshinori Uchida, MD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Tomohiro Inoue, MD, PhD: Department of Pathology, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Tetsuo Kondo, MD, PhD: Department of Pathology, Graduate School of Medicine University of Yamanashi, Chuo, Japan
Shinnosuke Ikemura, MD, PhD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan; Corresponding author. Address for correspondence: Shinnosuke Ikemura, MD, PhD, Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Kenzo Soejima, MD, PhD: Department of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, Chuo, Japan

Journal volume & issue: Vol. 5, no. 1
p. 100620

Abstract

Read online

Pulmonary neuroendocrine tumors are rare, accounting for approximately 1% to 2% of lung cancers. Atypical carcinoids account for approximately 10% of pulmonary neuroendocrine tumors and are categorized as moderately malignant. Treatment options for advanced-stage atypical carcinoids include everolimus, cytotoxic anticancer agents, and peptide receptor radionuclide therapy. In this report, we present the first case of KRAS G12C mutation-positive atypical carcinoid that was successfully treated with sotorasib. Therapeutically important mutations observed in non-small cell lung cancer are seldom found in atypical carcinoid tumors. Nonetheless, it is worthwhile to search for genetic mutations in atypical carcinoid tumors, considering the potential for molecular targeted therapy to be effective in their treatment as well.

Published in JTO Clinical and Research Reports

ISSN: 2666-3643 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/jto-clinical-and-research-reports/

About the journal

Abstract

Keywords