Zhongguo quanke yixue (Feb 2024)
Sleep Time and Risk of Senile Dementia: a Dose-response Meta-analysis
Abstract
Background With the accelerated aging of the national population, the rapid increase of the elderly with dementia has become an increasingly prominent problem. Sleep is the basic need of the human body, and sleep problems have become an independent risk factor for the cognitive function of the elderly. Moderate sleep duration is essential for the removal of brain wastes, synaptic plasticity, and the maintenance of normal function of the nervous system. However, the current sleep problems of the elderly have not attracted widespread attention, and the sleep time of the elderly needs to be further studied. Objective To explore the dose-response relationship between sleep duration and risk of senile dementia. Methods CNKI, Wanfang Data, VIP, CBM, PubMed, Cochrane Library, Embase and Web of Science databases were searched for prospective cohort studies on the relationship between sleep duration and risk of senile dementia from inception to June 2023. Literature data were independently extracted by two researchers, and literature quality evaluation was performed. Dose-response Meta-analysis was performed by applying restricted cubic spline regression model in Stata 16.0 software. Results A total of 9 papers with 58 342 study subjects and 9 887 exposures were included. Meta-analysis showed that sleep duration was associated with the risk of senile dementia (RR=1.32, 95%CI=1.17-1.48, P<0.05). The results of the subgroup analysis showed that the risk of senile dementia was increased by 19.2% in those with ≤6 h/d of sleep (RR=1.19, 95%CI=1.07-1.33, P<0.05) ; sleeping duration≥8 h/d increased the risk of senile dementia by 55.02% (RR=1.55, 95%CI=1.32-1.82, P<0.05). Dose-response meta-analysis results showed a U-shaped nonlinear relationship between sleep duration and risk of senile dementia (P<0.001). Compared with the reference sleep duration of 7 h/d, the risk of morbidity at each time point was as follows 5 h/d: RR=1.024, 95%CI=0.928-1.130; 5.5 h/d: RR=1.036, 95%CI=0.938-1.143; 6 h/d: RR=1.034, 95%CI=0.952-1.124; 6.5 h/d: RR=1.015, 95%CI=0.973-1.059; 7.5 h/d: RR=1.014, 95%CI=0.993-1.035; 8 h/d: RR=1.056, 95%CI=1.023-1.091; 8.5 h/d: RR=1.124, 95%CI=1.062-1.190; 9 h/d: RR=1.212, 95%CI=1.098-1.338; 9.5 h/d: RR=1.316, 95%CI=1.133-1.528; 10 h/d: RR=1.431, 95%CI=1.169-1.752. Conclusion There is a U-shaped nonlinear dose-response relationship between sleep duration and the risk of senile dementia, and the daily sleep duration ≥8 h will increase the risk of senile dementia.
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