Nature Communications (Apr 2017)
Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability
- Xiangxi Wang,
- Shi-Hua Li,
- Ling Zhu,
- Qing-Gong Nian,
- Shuai Yuan,
- Qiang Gao,
- Zhongyu Hu,
- Qing Ye,
- Xiao-Feng Li,
- Dong-Yang Xie,
- Neil Shaw,
- Junzhi Wang,
- Thomas S. Walter,
- Juha T. Huiskonen,
- Elizabeth E. Fry,
- Cheng-Feng Qin,
- David I. Stuart,
- Zihe Rao
Affiliations
- Xiangxi Wang
- National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
- Shi-Hua Li
- Department of Virology, Beijing Institute of Microbiology and Epidemiology
- Ling Zhu
- Division of Structural Biology, University of Oxford
- Qing-Gong Nian
- Department of Virology, Beijing Institute of Microbiology and Epidemiology
- Shuai Yuan
- National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
- Qiang Gao
- National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
- Zhongyu Hu
- National Institutes for Food and Drug Control
- Qing Ye
- Department of Virology, Beijing Institute of Microbiology and Epidemiology
- Xiao-Feng Li
- Department of Virology, Beijing Institute of Microbiology and Epidemiology
- Dong-Yang Xie
- Department of Virology, Beijing Institute of Microbiology and Epidemiology
- Neil Shaw
- National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
- Junzhi Wang
- National Institutes for Food and Drug Control
- Thomas S. Walter
- Division of Structural Biology, University of Oxford
- Juha T. Huiskonen
- Division of Structural Biology, University of Oxford
- Elizabeth E. Fry
- Division of Structural Biology, University of Oxford
- Cheng-Feng Qin
- Department of Virology, Beijing Institute of Microbiology and Epidemiology
- David I. Stuart
- Division of Structural Biology, University of Oxford
- Zihe Rao
- National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
- DOI
- https://doi.org/10.1038/s41467-017-00024-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Japanese encephalitis virus (JEV) is a Flavivirus responsible for thousands of deaths every year for which there are no specific anti-virals. Here, Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify structural elements that modulate stability and virulence.
