Oxytocin receptor DNA methylation is associated with exogenous oxytocin needs during parturition and postpartum hemorrhage

Abstract

Erickson et al. compare OXTR DNA methylation in individuals who experienced a postpartum hemorrhage arising from uterine atony and matched controls. Those with higher OXTR DNA methylation required more oxytocin during parturition and had a higher risk of postpartum hemorrhage.