Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

Rhiannon Morris; Yaoyuan Zhang; Julia I. Ellyard; Carola G. Vinuesa; James M. Murphy; Artem Laktyushin; Nadia J. Kershaw; Jeffrey J. Babon

doi:10.1038/s41467-021-26394-6

Nature Communications (Oct 2021)

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

Rhiannon Morris,
Yaoyuan Zhang,
Julia I. Ellyard,
Carola G. Vinuesa,
James M. Murphy,
Artem Laktyushin,
Nadia J. Kershaw,
Jeffrey J. Babon

Affiliations

Rhiannon Morris: Walter and Eliza Hall Institute of Medical Research
Yaoyuan Zhang: Australia Department of Immunology and Infectious Diseases, Australian National University
Julia I. Ellyard: Australia Department of Immunology and Infectious Diseases, Australian National University
Carola G. Vinuesa: Australia Department of Immunology and Infectious Diseases, Australian National University
James M. Murphy: Walter and Eliza Hall Institute of Medical Research
Artem Laktyushin: Walter and Eliza Hall Institute of Medical Research
Nadia J. Kershaw: Walter and Eliza Hall Institute of Medical Research
Jeffrey J. Babon: Walter and Eliza Hall Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-021-26394-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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LNK is a potent negative regulator of cytokine signaling implicated in blood cells proliferation. Here the authors present structures of the substrate recognition (SH2) domain of LNK in complex with phosphorylated motifs from JAK2 and EPOR; providing insight into its binding specificity and mode of action.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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