Nature Communications (Sep 2020)

Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

  • Aaron S. Schwartz-Duval,
  • Christian J. Konopka,
  • Parikshit Moitra,
  • Enrique A. Daza,
  • Indrajit Srivastava,
  • Elyse V. Johnson,
  • Taylor L. Kampert,
  • Stanley Fayn,
  • Anand Haran,
  • Lawrence W. Dobrucki,
  • Dipanjan Pan

DOI
https://doi.org/10.1038/s41467-020-17595-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Intracellular generation of gold nanoparticles has drawn attention but toxic effects have limited potential applications. Here, the authors report on the delivery of ionic gold with PEG resulting in faster synthesis and reduced toxicity due to lower concentrations of ionic gold required and explore potential applications.